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Inflammatory arthritis

Are the origins of adult arthritis seeded during embryonic development?

Nature Reviews Rheumatology volume 19, pages 132–133 (2023)Cite this article

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The phenotypic and functional heterogeneity of synovial tissue fibroblasts are well described, whereas the cellular and molecular mechanisms that establish this diverse fibroblast repertoire in the adult joint have remained unclear. When is the fate of synovial fibroblast repertoire determined, and what are the consequences for arthritis development as adults?

Refers to Collins, F. L. et al. Taxonomy of fibroblasts and progenitors in the synovial joint at single-cell resolution. Ann. Rheum. Dis. https://doi.org/10.1136/ard-2021-221682 (2022).

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Fig. 1: Determinants of fibroblast diversity in the adult mouse synovium.

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Acknowledgements

A.P.C. is supported by the Kennedy Trust for Rheumatology Research and A.H. is supported by Versus Arthritis.

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  1. Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK

    Annie Hackland & Adam P. Croft

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  1. Annie Hackland
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  2. Adam P. Croft
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Correspondence to Adam P. Croft.

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The authors declare no competing interests.

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Hackland, A., Croft, A.P. Are the origins of adult arthritis seeded during embryonic development?. Nat Rev Rheumatol 19, 132–133 (2023). https://doi.org/10.1038/s41584-023-00911-x

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