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Spondyloarthritis

ERAP1 and the return of the UPR in ankylosing spondylitis

Nature Reviews Rheumatology volume 19, pages 134–135 (2023)Cite this article

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The mechanisms underlying the genetic association between HLA-B27 and ankylosing spondylitis, including the contribution of endoplasmic reticulum aminopeptidase 1 (ERAP1), continue to elude the field. New findings support the involvement of the unfolded protein response and highlight the therapeutic potential and limitations of targeting ERAP1 in this disease.

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Authors and Affiliations

  1. Schroder Arthritis Institute, Krembil Research Institute, Division of Rheumatology, University Health Network, Toronto, Ontario, Canada

    Nigil Haroon & Robert D. Inman

  2. Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

    Robert D. Inman

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  1. Nigil Haroon
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  2. Robert D. Inman
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Correspondence to Nigil Haroon.

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Haroon, N., Inman, R.D. ERAP1 and the return of the UPR in ankylosing spondylitis. Nat Rev Rheumatol 19, 134–135 (2023). https://doi.org/10.1038/s41584-023-00910-y

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