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Systemic lupus erythematosus

Hydroxychloroquine dose: balancing toxicity and SLE flare risk

Contemporary guidelines for the management of systemic lupus erythematosus (SLE) recommend prescribing hydroxychloroquine dosages of 5 mg/kg per day or lower to minimize toxicity. However, new evidence raises serious concerns about the risk of SLE flare associated with such doses. How do the benefits and risks of this controversial recommendation balance out?

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Correspondence to Nathalie Costedoat-Chalumeau.

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Lenfant, T., Costedoat-Chalumeau, N. Hydroxychloroquine dose: balancing toxicity and SLE flare risk. Nat Rev Rheumatol 19, 6–7 (2023).

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