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SYSTEMIC LUPUS ERYTHEMATOSUS

Ikaros, Aiolos and other moving targets to treat SLE

Although the multitude of pathways involved in the pathogenesis of systemic lupus erythematosus (SLE) seem to be interconnected, each predominates in only a fraction of patients. This complexity means that many agents tested in SLE clinical trials — now including iberdomide — produce only a small clinical benefit.

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Fig. 1: E3 ubiquitin ligases in the pathogenesis of SLE.

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Correspondence to George C. Tsokos.

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Boulougoura, A., Tsokos, G.C. Ikaros, Aiolos and other moving targets to treat SLE. Nat Rev Rheumatol 18, 499–500 (2022). https://doi.org/10.1038/s41584-022-00815-2

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