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Ikaros, Aiolos and other moving targets to treat SLE

Although the multitude of pathways involved in the pathogenesis of systemic lupus erythematosus (SLE) seem to be interconnected, each predominates in only a fraction of patients. This complexity means that many agents tested in SLE clinical trials — now including iberdomide — produce only a small clinical benefit.

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Fig. 1: E3 ubiquitin ligases in the pathogenesis of SLE.


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Correspondence to George C. Tsokos.

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Boulougoura, A., Tsokos, G.C. Ikaros, Aiolos and other moving targets to treat SLE. Nat Rev Rheumatol 18, 499–500 (2022).

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