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Does psoriasis treatment affect PsA development?

The results of several retrospective studies have reported that systemic treatment in patients with psoriasis reduces the risk of incident psoriatic arthritis (PsA). Although encouraging from a prevention perspective, such studies are limited in their ability to provide a conclusive understanding of PsA risk, preventing a clear picture from emerging.

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  1. 1.

    Scher, J. U. et al. Preventing psoriatic arthritis: focusing on patients with psoriasis at increased risk of transition. Nat. Rev. Rheumatol. 15, 153–166 (2019).

    Article  Google Scholar 

  2. 2.

    Acosta Felquer, M. L. et al. Treating the skin with biologics in patients with psoriasis decreases the incidence of psoriatic arthritis. Ann. Rheum. Dis. (2021).

    Article  PubMed  Google Scholar 

  3. 3.

    Gisondi, P. et al. Biological disease-modifying antirheumatic drugs may mitigate the risk of psoriatic arthritis in patients with chronic plaque psoriasis. Ann. Rheum. Dis. (2021).

    Article  PubMed  Google Scholar 

  4. 4.

    Shalev Rosenthal, Y. et al. Psoriatic arthritis incidence among patients receiving biologic medications for psoriasis: a nested case control study. Arthritis Rheumatol. (2021).

    Article  PubMed  Google Scholar 

  5. 5.

    Haberman, R. et al. Bridging the gaps in the care of psoriasis and psoriatic arthritis: the role of combined clinics. Curr. Rheumatol. Rep. 20, 76 (2018).

    Article  Google Scholar 

  6. 6.

    Ogdie, A. et al. Body surface area affected by psoriasis and the risk for psoriatic arthritis: a prospective population-based cohort study. Rheumatology (2021).

    Article  PubMed  Google Scholar 

  7. 7.

    Ogdie, A. et al. Longitudinal analysis of the patient pathways to diagnosis of psoriatic arthritis. Arthritis Res. Ther. 23, 252 (2021).

    Article  Google Scholar 

  8. 8.

    Nguyen, U.-S. D. T. et al. Smoking paradox in the development of psoriatic arthritis among patients with psoriasis: a population-based study. Ann. Rheum. Dis. 77, 119–123 (2018).

    Article  Google Scholar 

  9. 9.

    Bell, S. et al. Aiming for cure and preventive initiatives in psoriatic disease: building synergy at NPF, GRAPPA, and PPACMAN. Curr. Rheumatol. Rep. 22, 78 (2020).

    Article  Google Scholar 

  10. 10.

    Hernan, M.A. & Robins, J. M. Causal Inference: What If (Boca Raton: Chapman & Hall, 2020).

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The authors wish to acknowledge C. Ritchlin, J. Scher, J. Gelfand and the PAMPA study group dedicated to investigating opportunities in the prevention of psoriatic arthritis.

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Corresponding author

Correspondence to Joseph F. Merola.

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Competing interests

J.F.M. declares he is a consultant and/or investigator for Abbvie, Amgen, Biogen, BMS, Dermavant, Eli Lilly, Janssen, Leo Pharma, Novartis, Pfizer, Regeneron, Sanofi, Sun Pharma and UCB. A.O. declares she has consulted for Abbvie, Amgen, BMS, Celgene, CorEvitas, Gilead, Janssen, Lilly, Novartis, Pfizer and UCB and has received grants from Abbvie, Novartis and Pfizer to the University of Pennsylvania and Amgen to the Forward Databank. Her spouse has received royalties from Novartis.

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Merola, J.F., Ogdie, A. Does psoriasis treatment affect PsA development?. Nat Rev Rheumatol 17, 708–709 (2021).

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