In contrast to anecdotal reports that pre-existing use of NSAIDs is linked to poor outcomes in patients with COVID-19, the findings of a prospective, multicentre cohort study found no increase in mortality or COVID-19 severity among NSAID users. The study included 72,179 patients across 255 health-care facilities in England, 4,211 (5.8%) of whom were taking systemic NSAIDs before they were admitted to hospital.
Drake, T. M. et al. Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study. Lancet https://doi.org/10.1016/S2665-9913(21)00104-1 (2021)
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Onuora, S. NSAIDs not linked to worse COVID-19 outcomes. Nat Rev Rheumatol 17, 378 (2021). https://doi.org/10.1038/s41584-021-00645-8