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DEVELOPMENTAL BIOLOGY

Keep your Sox on, chondrocytes!

Nature Reviews Rheumatology volume 17, pages 383–384 (2021)Cite this article

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The transcription factor Sox9 is important for cartilage formation during development, but its role in postnatal growth plates and adult articular cartilage has been uncertain. New research is revealing essential roles for Sox9 in postnatal cartilage homeostasis and in preventing post-traumatic osteoarthritis, along with new mechanisms for chondrocyte-to-osteoblast transition.

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Fig. 1: Role of Sox9 in determining chondrocyte fate.

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Authors and Affiliations

  1. Skeletal Biology Group, Department of Comparative Biomedical Sciences, Royal Veterinary College, London, UK

    Andrew A. Pitsillides

  2. Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada

    Frank Beier

  3. Bone and Joint Institute, University of Western Ontario, London, Ontario, Canada

    Frank Beier

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  1. Andrew A. Pitsillides
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  2. Frank Beier
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Correspondence to Andrew A. Pitsillides or Frank Beier.

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Pitsillides, A.A., Beier, F. Keep your Sox on, chondrocytes!. Nat Rev Rheumatol 17, 383–384 (2021). https://doi.org/10.1038/s41584-021-00628-9

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