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RHEUMATOID ARTHRITIS

Serum proteome altered in pre-RA

Nature Reviews Rheumatology volume 16, page 538 (2020)Cite this article

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Researchers have identified a pre-clinical proteomic signature that can predict future onset of rheumatoid arthritis (RA) in at-risk individuals (area under the curve 0.913, accuracy 91.2%). The signature was developed by analysing serum samples from a cohort of first-degree relatives of indigenous North American patients with RA. Differences in the serum proteome between those who progressed to develop RA and the other at-risk individuals were present years before disease onset (median 30.9 months), irrespective of ACPA status.

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  1. Nature Reviews Rheumatology

    Sarah Onuora

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  1. Sarah Onuora
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Correspondence to Sarah Onuora.

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Onuora, S. Serum proteome altered in pre-RA. Nat Rev Rheumatol 16, 538 (2020). https://doi.org/10.1038/s41584-020-0494-1

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  • DOI: https://doi.org/10.1038/s41584-020-0494-1

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