Pain in osteoarthritis is multifactorial, but a disconnect between radiographic features and symptoms hampers our understanding of pain. New imaging data suggest that pain arises from virtually all structures in the joint and that cartilage loss is only a minor contributor to pain symptoms but is important for disease progression.
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The salary of G.J. is provided by NHMRC Australia. No sources of funding were used to assist in the preparation of this study.
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Jones, G. Pain in OA: is cartilage loss a major contributor?. Nat Rev Rheumatol 16, 541–542 (2020). https://doi.org/10.1038/s41584-020-0484-3
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DOI: https://doi.org/10.1038/s41584-020-0484-3
