Data on 477 patients with axial spondyloarthritis (axSpA) from the Corrona psoriatic arthritis/spondyloarthritis registry (a prospective observational cohort from the USA) have revealed links between the presence of enthesitis and poor outcomes. Patients with axSpA who had enthesitis were more likely to be female, have non-radiographic disease and have a history of depression or fibromyalgia, as well as having greater disease activity (according to several measures) and worse quality of life than patients with axSpA who did not have enthesitis.