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IMMUNOLOGY

Learning from similarities between vaccine responses and SLE

Baseline immune variation predicts immune responses during vaccination, and the gene signatures capturing such immune variation seem to correlate with systemic lupus erythematosus (SLE) disease activity. Will the definition of these gene sets enable the development of the much needed concept of personalized medicine in SLE?

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Fig. 1: A basal gene expression profile determines immune responses.

References

  1. Barrat, F. J., Crow, M. K. & Ivashkiv, L. B. Interferon target-gene expression and epigenomic signatures in health and disease. Nat. Immunol. 20, 1574–1583 (2019).

    Article  CAS  PubMed  Google Scholar 

  2. Nielsen, P. R. et al. Infections as risk factor for autoimmune diseases - a nationwide study. J. Autoimmun. 74, 176–181 (2016).

    Article  PubMed  Google Scholar 

  3. Kotliarov, Y. et al. Broad immune activation underlies shared set point signatures for vaccine responsiveness in healthy individuals and disease activity in patients with lupus. Nat. Med. 26, 618–629 (2020).

    Article  CAS  PubMed  Google Scholar 

  4. Thorlacius, G. E., Wahren-Herlenius, M. & Rönnblom, L. An update on the role of type I interferons in systemic lupus erythematosus and Sjögren’s syndrome. Curr. Opin. Rheumatol. 30, 471–481 (2018).

    Article  CAS  PubMed  Google Scholar 

  5. Chiche, L. et al. Modular transcriptional repertoire analyses of adults with systemic lupus erythematosus reveal distinct type I and type II interferon signatures. Arthritis Rheumatol. 66, 1583–1595 (2014).

    Article  CAS  PubMed  Google Scholar 

  6. Tsang, J. S. et al. Global analyses of human immune variation reveal baseline predictors of postvaccination responses. Cell 157, 499–513 (2014).

    Article  CAS  PubMed  Google Scholar 

  7. Banchereau, R. et al. Personalized immunomonitoring uncovers molecular networks that stratify lupus patients. Cell 165, 551–565 (2016).

    Article  CAS  PubMed  Google Scholar 

  8. Reid, S. et al. High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus. Ann. Rheum. Dis. 79, 363–369 (2020).

    Article  PubMed  Google Scholar 

  9. Brauner, S. et al. H1N1 vaccination in Sjögren’s syndrome triggers polyclonal B cell activation and promotes autoantibody production. Ann. Rheum. Dis. 76, 1755–1763 (2017).

    Article  CAS  PubMed  Google Scholar 

  10. Björk, A. et al. Viral antigens elicit augmented immune responses in primary Sjögren’s syndrome. Rheumatology https://doi.org/10.1093/rheumatology/kez509 (2019).

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

The authors thank the Swedish Research Council, the Heart-Lung Foundation, the Swedish Rheumatism Association, the King Gustaf the Vth 80-year Foundation and the Swedish Society of Medicine with the Ingegerd Johansson donation for provision of funding.

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Correspondence to Lars Rönnblom.

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Interferome: www.interferome.org

The Human Protein Atlas: www.proteinatlas.org

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Wahren-Herlenius, M., Rönnblom, L. Learning from similarities between vaccine responses and SLE. Nat Rev Rheumatol 16, 355–356 (2020). https://doi.org/10.1038/s41584-020-0421-5

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