Interest in therapies for psoriatic arthritis (PsA) has increased in response to recognition that many patients remain undiagnosed and are inadequately treated. In 2020, advances in PsA treatments have included phase III trials of an IL-23 inhibitor, head-to-head trials of IL-17 inhibition against TNF inhibition and updated EULAR treatment guidelines.
Key advances
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Updated EULAR treatment recommendations for psoriatic arthritis (PsA) include newly approved medications, recognize the need for treatment tailored to the individual and encourage targets of remission or low disease activity2.
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Guselkumab, the first of a new class of drugs that inhibit the p19 subunit of IL-23, was approved for PsA on the basis of results from two phase III clinical trials3,4.
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Head-to-head trials of IL-17 inhibition against TNF inhibition confirmed similar efficacy of both therapies in musculoskeletal domains of PsA and superior efficacy of IL-17 inhibition in the psoriasis domain5,6.
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References
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P.M. declares that he has received research grants, consultation fees and/or speaker honoraria from AbbVie, Amgen, Boehringer Ingelheim, Bristol Myers Squibb, Eli Lilly, Galapagos, Gilead, GlaxoSmithKline, Janssen, Novartis, Pfizer, SUN Pharma and UCB.
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Mease, P.J. New treatments for PsA meet targeted therapy goals. Nat Rev Rheumatol 17, 77–78 (2021). https://doi.org/10.1038/s41584-020-00561-3
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DOI: https://doi.org/10.1038/s41584-020-00561-3
