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OSTEOARTHRITIS

IL-33 is a potential new target in OA

Nature Reviews Rheumatology volume 17, page 3 (2021)Cite this article

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Osteoarthritis (OA) is the most common form of arthritis worldwide, yet effective treatments are lacking, leading researchers to constantly search for plausible new treatment targets. One such target is IL-33, a member of the IL-1 cytokine family. According to the results of a new study, blockade of IL-33 has the potential to reduce both pain and joint damage in experimental OA.

Sacitharan and colleagues first examined tissue from patients with OA and found an upregulation of IL-33 in the synovial fluid, and of both IL-33 and its receptor ST2 in chondrocytes. Exogenous IL-33 caused human chondrocytes to produce cartilage-degrading proteases in vitro and exacerbated disease in mice with experimental OA induced by destabilization of the medial meniscus (DMM).

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References

Original article

  • He, Z. et al. Blockade of IL-33 signalling attenuates osteoarthritis. Clin. Transl Immunol. 9, e1185 (2020)

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Related article

  • Dinarello, C. A. The IL-1 family of cytokines and receptors in rheumatic diseases. Nat. Rev. Rheumatol. 15, 612–632 (2019)

    Article  CAS  Google Scholar 

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  1. Nature Reviews Rheumatology http://www.nature.com/nrrheum/

    Joanna Clarke

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  1. Joanna Clarke
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Correspondence to Joanna Clarke.

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Clarke, J. IL-33 is a potential new target in OA. Nat Rev Rheumatol 17, 3 (2021). https://doi.org/10.1038/s41584-020-00542-6

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  • DOI: https://doi.org/10.1038/s41584-020-00542-6

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