Registry data from a long-term observation study of patients with juvenile idiopathic arthritis (JIA) suggest that DMARD exposure does not increase the risk of major adverse pregnancy outcomes in patients with JIA. Among the 152 pregnancies in 98 women with JIA and 39 pregnancies involving men with JIA as partners, the rates of miscarriage (13.1%) and major congenital anomaly (3.6%) were similar to the expected background rates. Half of the pregnancies were unplanned and occurred during treatment with DMARDs. Elective abortions were also common in DMARD-exposed pregnancies.
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Drechsel, P. et al. Pregnancy outcomes in DMARD-exposed patients with juvenile idiopathic arthritis—results from a JIA biologic registry. Rheumatology. https://doi.org/10.1093/rheumatology/kez309 (2019)
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McHugh, J. Pregnancy outcomes in patients with JIA. Nat Rev Rheumatol 15, 574 (2019). https://doi.org/10.1038/s41584-019-0301-z
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DOI: https://doi.org/10.1038/s41584-019-0301-z
