Remission in rheumatoid arthritis: missing objectives by using inadequate DAS28 targets

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For too long, the definition of ‘remission’ in rheumatoid arthritis has been distorted by the widespread use of an inadequate tool, with consequences for clinical care and for making sense of clinical trial data. Has the time come to move away from DAS28-defined remission?

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Fig. 1: Distinct effects of different therapies on DAS28-defined remission.


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Correspondence to Daniel Aletaha or Josef S. Smolen.

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Competing interests

D. Aletaha declares that he has received personal fees from AbbVie, Eli Lilly, Janssen, Medac, Merck Sharp & Dohme, Pfizer, Roche, Sanofi/Genzyme and UCB, and grants from AbbVie, Bristol-Myers Squibb, and Merck Sharp & Dohme. J.S. Smolen declares that he has received grants for his institution from AbbVie, AstraZeneca, Janssen, Eli Lilly, Merck Sharp & Dohme, Novartis, Pfizer and Roche, and that he has provided expert advice or had symposia speaking engagements for AbbVie, Amgen, AstraZeneca, Astro, Bristol-Myers Squibb, Celgene, Celltrion, Chugai, Gilead, ILTOO, Janssen, Eli Lilly, Merck Sharp & Dohme, Novartis-Sandoz, Pfizer, Roche, Samsung, Sanofi and UCB.

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