Cartilage has a limited healing capacity; however, studies into the basic biological characteristics, formation and structural maintenance of the cartilage collagen network are providing explanations for the failure of current therapeutic approaches, urging us to rethink our approach to the regeneration of articular cartilage.
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The authors acknowledge the Dutch Arthritis Foundation (LLP-12 (to J.M.) and LLP-22 (to P.R.v.W.)), and the Netherlands Organization for Scientific Research (Materials Driven Regeneration, 024.003.013 (to J.M.)) for financial support.
The authors declare no competing interests.
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Malda, J., Groll, J. & van Weeren, P.R. Rethinking articular cartilage regeneration based on a 250-year-old statement. Nat Rev Rheumatol 15, 571–572 (2019). https://doi.org/10.1038/s41584-019-0278-7
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