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Rethinking articular cartilage regeneration based on a 250-year-old statement

Nature Reviews Rheumatology volume 15, pages 571–572 (2019)Cite this article

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Cartilage has a limited healing capacity; however, studies into the basic biological characteristics, formation and structural maintenance of the cartilage collagen network are providing explanations for the failure of current therapeutic approaches, urging us to rethink our approach to the regeneration of articular cartilage.

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Acknowledgements

The authors acknowledge the Dutch Arthritis Foundation (LLP-12 (to J.M.) and LLP-22 (to P.R.v.W.)), and the Netherlands Organization for Scientific Research (Materials Driven Regeneration, 024.003.013 (to J.M.)) for financial support.

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Authors and Affiliations

  1. Department of Orthopaedics, University Medical Centre Utrecht, Utrecht, Netherlands

    Jos Malda

  2. Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands

    Jos Malda & P. René van Weeren

  3. Department of Functional Materials in Medicine and Dentistry and the Bavarian Polymer Institute, University of Würzburg, Würzburg, Germany

    Jürgen Groll

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  1. Jos Malda
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  2. Jürgen Groll
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  3. P. René van Weeren
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Correspondence to Jos Malda.

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Malda, J., Groll, J. & van Weeren, P.R. Rethinking articular cartilage regeneration based on a 250-year-old statement. Nat Rev Rheumatol 15, 571–572 (2019). https://doi.org/10.1038/s41584-019-0278-7

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