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Helminths and microbiota — partners in arthritis prevention?

Nature Reviews Rheumatology volume 15, pages 454–455 (2019)Cite this article

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Changes in the gut microbiome are thought to be important environmental triggers for inflammatory forms of arthritis, including rheumatoid arthritis. Could interactions between gut parasites, such as helminths, and gut microbiota be the key to normalizing an unbalanced microbiome and preventing arthritis?

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References

  1. Scher, J. U. et al. Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. eLife 2, e01202 (2013).

    PubMed  PubMed Central  Google Scholar 

  2. Zhang, X. et al. The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment. Nat. Med. 21, 895–905 (2015).

    CAS  PubMed  Google Scholar 

  3. Doonan, J. et al. The parasitic worm product ES-62 normalises the gut microbiota bone marrow axis in inflammatory arthritis. Nat. Commun. 10, 1554 (2019).

    PubMed  PubMed Central  Google Scholar 

  4. Segata, N. Gut microbiome: westernization and the disappearance of intestinal diversity. Curr. Biol. 25, R611–R613 (2015).

    CAS  PubMed  Google Scholar 

  5. Maizels, R. M. Parasitic helminth infections and the control of human allergic and autoimmune disorders. Clin. Microbiol. Infect. 22, 481–486 (2016).

    CAS  PubMed  Google Scholar 

  6. Rapin, A. & Harris, N. L. Helminth-bacterial interactions: cause and consequence. Trends Immunol. 39, 724–733 (2018).

    CAS  PubMed  Google Scholar 

  7. McInnes, I. B. et al. A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62. J. Immunol. 171, 2127–2133 (2003).

    CAS  PubMed  Google Scholar 

  8. Rodgers, D. T. et al. The parasitic worm product ES-62 targets myeloid differentiation factor 88-dependent effector mechanisms to suppress antinuclear antibody production and proteinuria in MRL/lpr mice. Arthritis Rheumatol. 67, 1023–1035 (2015).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Scher, J. U. & Abramson, S. B. The microbiome and rheumatoid arthritis. Nat. Rev. Rheumatol. 7, 569–578 (2011).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Begka, C. & Marsland, B. J. Make (no) bones about butyrate. Immunity 49, 994–996 (2018).

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Immunology and Pathology, Central Clinical School, Monash University, The Alfred Centre, Melbourne, Victoria, Australia

    Gillian Coakley & Nicola L. Harris

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  1. Gillian Coakley
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  2. Nicola L. Harris
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Correspondence to Nicola L. Harris.

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The authors declare no competing interests.

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Coakley, G., Harris, N.L. Helminths and microbiota — partners in arthritis prevention?. Nat Rev Rheumatol 15, 454–455 (2019). https://doi.org/10.1038/s41584-019-0253-3

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