A genomic screen of uncultivated human gut microorganisms from diverse global locations has revealed 2,058 previously unknown operational taxonomic units (OTUs) at a species level. One of these newly identified gut bacteria, OTU-14148, a species in the Negativicutes class, was associated with ankylosing spondylitis (AS). OTU-14148 was present at lower amounts in the stool of patients with AS than in that of healthy individuals and had an eightfold greater association with AS than the next most strongly associated species.
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Nayfach, S. et al. Novel insights from uncultivated genomes of the global human gut microbiome. Nature https://doi.org/10.1038/s41586-019-1058-x (2019)
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Collison, J. New species of gut bacteria associated with AS. Nat Rev Rheumatol 15, 250 (2019). https://doi.org/10.1038/s41584-019-0209-7
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DOI: https://doi.org/10.1038/s41584-019-0209-7
