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Cholesterol and cartilage do not mix well

The molecular mechanisms responsible for initiation and progression of osteoarthritis (OA) are incompletely understood. New data implicate cholesterol, its metabolites and the receptor RORα as catabolic drivers of OA-like disease in mice, but do these data identify new targets for treating patients with OA?

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The author thanks the Canadian Institutes of Health Research (CIHR), the Arthritis Society and the Canada Research Chair Program for funding his research, and all the members of his lab for ongoing discussions.

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Correspondence to Frank Beier.

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The author declares no competing interests.

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Beier, F. Cholesterol and cartilage do not mix well. Nat Rev Rheumatol 15, 253–254 (2019).

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