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ACPA epitopes — what are we actually looking at?

Nature Reviews Rheumatology volume 15, pages 130–132 (2019)Cite this article

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The use of assays to detect anti-citrullinated protein antibodies (ACPAs) is helpful in the diagnosis of rheumatoid arthritis. But how good are these assays at detecting ACPAs and do we really know what the results are telling us about ACPA specificity?

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Fig. 1: Fine-specificity and cross-reactivity of anti-citrullinated protein antibodies.

References

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Authors and Affiliations

  1. Amsterdam Rheumatology and Immunology Center, Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands

    Lotte A. van de Stadt

  2. Department of Immunopathology, Sanquin Research, Amsterdam, Netherlands

    Theo Rispens

  3. AMC–Sanquin Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands

    Theo Rispens

Authors
  1. Lotte A. van de Stadt
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  2. Theo Rispens
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Correspondence to Theo Rispens.

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van de Stadt, L.A., Rispens, T. ACPA epitopes — what are we actually looking at?. Nat Rev Rheumatol 15, 130–132 (2019). https://doi.org/10.1038/s41584-018-0157-7

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