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ACPA epitopes — what are we actually looking at?

Nature Reviews Rheumatologyvolume 15pages130132 (2019) | Download Citation

The use of assays to detect anti-citrullinated protein antibodies (ACPAs) is helpful in the diagnosis of rheumatoid arthritis. But how good are these assays at detecting ACPAs and do we really know what the results are telling us about ACPA specificity?

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Author information

Affiliations

  1. Amsterdam Rheumatology and Immunology Center, Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands

    • Lotte A. van de Stadt
  2. Department of Immunopathology, Sanquin Research, Amsterdam, Netherlands

    • Theo Rispens
  3. AMC–Sanquin Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands

    • Theo Rispens

Authors

  1. Search for Lotte A. van de Stadt in:

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Competing interests

The authors declare no competing interests.

Corresponding author

Correspondence to Theo Rispens.

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DOI

https://doi.org/10.1038/s41584-018-0157-7

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