Targeting the TLR4–MD2 axis in systemic sclerosis

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Inappropriate activation of Toll-like receptor 4 (TLR4) on resident fibroblasts, through the binding of damage-associated molecular patterns, is a potential driver of fibrosis in systemic sclerosis. New evidence suggests that targeting fibroblast-specific TLR4 or an accessory molecule MD2 could have therapeutic value.

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Fig. 1: Targeting TLR4–MD2 signalling in fibroblast activation.


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Correspondence to Steven O’Reilly.

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