Testing the anti-osteoclastic function of biologic DMARDs

A variety of biologic DMARDs now exist for the treatment of rheumatoid arthritis, but we don’t really know how these drugs function in vivo. Can time-lapse intravital imaging distinguish the modes of action of DMARDs by comparing response to joint destruction in mouse models of arthritis?

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Fig. 1: Biologic DMARD mechanisms.


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The authors thank S. Paolino, S. Soldano, R. Brizzolara and staff members at the Research Laboratory and Division of Clinical Rheumatology of the University of Genova for their support in the compilation of the manuscript.

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Correspondence to Maurizio Cutolo.

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Competing interests

M.C. declares he has received university research funds from Actelion Pharmaceuticals Ltd, Boehringer Ingelheim, Bristol-Myers Squibb, Celgene, and Horizon Pharma. A.S. declares no competing interests.

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Cutolo, M., Sulli, A. Testing the anti-osteoclastic function of biologic DMARDs. Nat Rev Rheumatol 14, 446–448 (2018). https://doi.org/10.1038/s41584-018-0046-0

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