After more than 25 years of development, arthritis gene therapy is finally entering clinical practice. In South Korea, a gene therapeutic has been approved for the treatment of osteoarthritis, and other gene therapeutics are in the pipeline elsewhere. Genetic medicines for arthritis should enter the rheumatological armamentarium in the foreseeable future.
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References
US Food and Drug Administration. Approved cellular and gene therapy products. US Food and Drug Administration. FDA https://www.fda.gov/BiologicsBloodVaccines/CellularGeneTherapyProducts/ApprovedProducts/default.htm (2018).
Evans, C. H., Ghivizzani, S. C. & Robbins, P. D. Gene delivery to joints by intra-articular injection. Hum. Gene Ther. 29, 2–14 (2018).
Watson, R. S. et al. scAAV-mediated gene transfer of interleukin-1 receptor antagonist to synovium and articular cartilage in large mammalian joints. Gene Ther. 20, 670–677 (2013).
Ruan, M. Z. et al. Proteoglycan 4 expression protects against the development of osteoarthritis. Sci. Transl Med. 5, 176ra134 (2013).
Kim, M. K. et al. A multicenter, double-blind, phase III clinical trial to evaluate the efficacy and safety of a cell and gene therapy in knee osteoarthritis patients. Hum. Gene Ther. Clin. Dev. https://doi.org/10.1089/hum.2017.249 (2018).
Cherian, J. J. et al. Preliminary results of a phase II randomized study to determine the efficacy and safety of genetically engineered allogeneic human chondrocytes expressing TGF-β in patients with grade 3 chronic degenerative joint disease of the knee. Osteoarthritis Cartilage 23, 2109–2118 (2015).
US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02790723 (2017).
US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02727764 (2018).
Acknowledgements
The work of C.H.E., S.C.G. and P.D.R. in this area has been funded by multiple grants from the National Institute of Arthritis and Musculoskeletal Skin Diseases (NIAMS) and the National Institute on Aging (NIA) and the US Department of Defense.
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C.H.E and P.D.R. declare that they are on the scientific advisory board of TissueGene Inc. S.C.G declares no competing interests
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Evans, C.H., Ghivizzani, S.C. & Robbins, P.D. Arthritis gene therapy is becoming a reality. Nat Rev Rheumatol 14, 381–382 (2018). https://doi.org/10.1038/s41584-018-0009-5
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DOI: https://doi.org/10.1038/s41584-018-0009-5
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