A growing body of epidemiological evidence linking air pollution to multiple brain disorders suggests that these adverse effects are produced by mechanisms that are shared across these disorders. More stringent, targeted regulatory policies may therefore be required to ensure public health protection.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Rent or buy this article
Prices vary by article type
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Pirlea, F. & Huang, W. V. The Global Distribution of Air Pollution https://datatopics.worldbank.org/world-development-indicators/stories/the-global-distribution-of-air-pollution.html (The World Bank, 2019).
O’Piela, D. R., Durisek, G. R., Escobar, Y.-N. H., Mackos, A. R. & Wold, L. E. Particulate matter and Alzheimer’s disease: an intimate connection. Trends Mol. Med. 28, 770–780 (2022).
Lin, C.-K., Chang, Y.-T., Lee, F.-S., Chen, S.-T. & Christiani, D. Association between exposure to ambient particulate matters and risks of autism spectrum disorder in children: a systematic review and exposure-response meta-analysis. Environ. Res. Lett. 16, 063003 (2021).
Cory-Slechta, D. A., Merrill, A. & Sobolewski, M. Air pollution-related neurotoxicity across the life span. Annu. Rev. Pharmacol. Toxicol. https://doi.org/10.1146/annurev-pharmtox-051921-020812 (2022).
D’Errico, J. N., Doherty, C., Reyes George, J. J., Buckley, B. & Stapleton, P. A. Maternal, placental, and fetal distribution of titanium after repeated titanium dioxide nanoparticle inhalation through pregnancy. Placenta 121, 99–108 (2022).
Cox, A. et al. Evolution of nanoparticle protein corona across the blood–brain barrier. ACS Nano 12, 7292–7300 (2018).
Cory-Slechta, D. A., Sobolewski, M. & Oberdörster, G. Air pollution-related brain metal dyshomeostasis as a potential risk factor for neurodevelopmental disorders and neurodegenerative diseases. Atmosphere 11, 1098 (2020).
David, S., Jhelum, P., Ryan, F., Jeong, S. Y. & Kroner, A. Dysregulation of iron homeostasis in the central nervous system and the role of ferroptosis in neurodegenerative disorders. Antioxid. Redox Signal. 37, 150–170 (2022).
Hahad, O. et al. Ambient air pollution increases the risk of cerebrovascular and neuropsychiatric disorders through induction of inflammation and oxidative stress. Int. J. Mol. Sci. 21, 4306 (2020).
Wang, N., White, L. E., Qi, Y., Cofer, G. & Johnson, G. A. Cytoarchitecture of the mouse brain by high resolution diffusion magnetic resonance imaging. Neuroimage 216, 116876 (2020).
The authors declare no competing interests.
Peer review information
Nature Reviews Neuroscience thanks C. Thornton and A. D’Angiulli for their contribution to the peer review of this work.
About this article
Cite this article
Cory-Slechta, D.A., Sobolewski, M. Neurotoxic effects of air pollution: an urgent public health concern. Nat Rev Neurosci 24, 129–130 (2023). https://doi.org/10.1038/s41583-022-00672-8
This article is cited by
The evolution of atmospheric particulate matter in an urban landscape since the Industrial Revolution
Scientific Reports (2023)
Can green credit policy restrict the cross-region investment of heavy-polluting enterprises? Evidence from China
Environment, Development and Sustainability (2023)