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SLEEP

DNA damage drives sleep

Nature Reviews Neuroscience volume 23, page 69 (2022)Cite this article

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DNA damage increases during wakefulness and decreases during sleep, but how this is regulated is not completely understood. In the zebrafish dorsal pallium, DNA damage induced by neuronal activity or mutagenesis induced sleep and the recruitment of DNA repair mechanisms involving the DNA damage response (DDR) proteins Rad52 and Ku80. Moreover, the DDR initiator Parp1 was increased following sleep deprivation, and Parp1 administration promoted sleep in both larval and adult zebrafish. Last, inhibition of Parp1 decreased DNA repair during sleep. Overall, these findings identify DNA damage as a homeostatic regulator of sleep.

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  1. Nature Reviews Neuroscience http://www.nature.com/nrn/

    Sian Lewis

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  1. Sian Lewis
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Correspondence to Sian Lewis.

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Lewis, S. DNA damage drives sleep. Nat Rev Neurosci 23, 69 (2022). https://doi.org/10.1038/s41583-021-00550-9

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