Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Model potential

Human induced pluripotent stem cell (iPSC)-derived neurons could be used to model CNS development. Real et al. transplanted cultures of green fluorescent protein-expressing neurons and neural progenitors derived from human iPSCs into the somatosensory cortex of adult mice, and used multiphoton imaging to longitudinally track the grafts over 4 months. Grafts showed changes similar to those in developing human cortex, including axon growth, synapse formation and turnover, and oscillatory activity. By contrast, grafts derived from individuals with Down syndrome showed a lower synapse turnover rate, indicating that iPSC-derived cells can also be used to model aspects of neurodevelopmental disorders.


Original article

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Natasha Bray.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Bray, N. Model potential. Nat Rev Neurosci 20, 4 (2019).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing