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NEURODEGENERATIVE DISEASE

Complements lead to insults

Nature Reviews Neuroscience volume 20, pages 2–3 (2019)Cite this article

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Tauopathies such as Alzheimer disease (AD) are associated with neuroinflammation and synapse loss; however, the relationship between tau pathology and these features is unclear. Two studies now provide evidence in mice that tau pathology promotes the expression of complement system molecules, which drive neuroinflammation and the phagocytosis of synapses by microglia.

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  1. Nature Reviews Neuroscience http://www.nature.com/nrn/

    Natasha Bray

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  1. Natasha Bray
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Correspondence to Natasha Bray.

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Bray, N. Complements lead to insults. Nat Rev Neurosci 20, 2–3 (2019). https://doi.org/10.1038/s41583-018-0099-8

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  • DOI: https://doi.org/10.1038/s41583-018-0099-8

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