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Modelling microglial function with induced pluripotent stem cells: an update

Nature Reviews Neurosciencevolume 19pages445452 (2018) | Download Citation

Abstract

It is becoming increasingly apparent that microglia, the immune cells of the CNS, and their peripheral counterparts, macrophages, have a major role in normal physiology and pathology. Recent technological advances in the production of particular cell types from induced pluripotent stem cells have led to an interest in applying this methodology to the production of microglia. Here, we discuss recent advances in this area and describe how they will aid our future understanding of microglia.

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Affiliations

  1. Department of Neuroinflammation, University College London Institute of Neurology, London, UK

    • Jennifer M. Pocock
    •  & Thomas M. Piers

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Contributions

J.M.P. made a substantial contribution to discussions of the content of the article. J.M.P. and T.M.P. researched data for the article, wrote the article and reviewed and/or edited the manuscript before submission.

Competing interests

The authors declare no competing interests.

Corresponding authors

Correspondence to Jennifer M. Pocock or Thomas M. Piers.

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DOI

https://doi.org/10.1038/s41583-018-0030-3