Although chronic pain is one of the most important medical problems facing society, there has been very limited progress in the development of novel therapies for this condition. Here, we discuss high-impact research priorities to reduce the number of people transitioning from acute to chronic intractable pain.

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We thank the Interagency Pain Research Coordinating Committee of the US National Institutes of Health, who facilitated and provided financial support for meetings of the working group.

Author information


  1. The University of Texas at Dallas, Richardson, TX, USA

    • Theodore J. Price
  2. University of California, San Francisco, San Francisco, CA, USA

    • Allan I. Basbaum
    • , Jacqueline Bresnahan
    •  & Jon D. Levine
  3. National Fibromyalgia and Chronic Pain Association, Logan, UT, USA

    • Jan F. Chambers
  4. Laval University & CERVO Brain Research Centre, Québec, QC, Canada

    • Yves De Koninck
  5. Harvard University, Boston, MA, USA

    • Robert R. Edwards
    •  & Neil Schechter
  6. Duke University, Durham, NC, USA

    • Ru-Rong Ji
  7. York University, Toronto, ON, Canada

    • Joel Katz
  8. University of Texas MD Anderson Cancer Center, Houston, TX, USA

    • Annemieke Kavelaars
  9. National Institutes of Health, Bethesda, MD, USA

    • Linda Porter
  10. University of Iowa, Iowa City, IA, USA

    • Kathleen A. Sluka
  11. University of Washington, Seattle, WA, USA

    • Gregory W. Terman
  12. University of Colorado, Boulder, CO, USA

    • Tor D. Wager
  13. University of California, San Diego, San Diego, CA, USA

    • Tony L. Yaksh
  14. University of Rochester, Rochester, NY, USA

    • Robert H. Dworkin


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Competing interests

The authors declare no competing interests.

Corresponding author

Correspondence to Theodore J. Price.

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