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Cardiovascular risk factors for epilepsy and dementia

Risk factors for dementia accumulate during life, but the effect of concomitant diseases on cognitive decline across the lifespan is still undefined. A new study has shown that focal epilepsy is associated with a considerable risk of developing dementia, but that this effect is magnified by modifiable cardiovascular risk factors.

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Fig. 1: Risk factors for dementia.


  1. Global action plan on the public health response to dementia 2017–2025. World Health Organization (2017).

  2. Elahi, F. M., Wang, M. M. & Meschia, J. F. Cerebral small vessel disease-related dementia: more questions than answers. Stroke 54, 648–660 (2023).

    Article  PubMed  Google Scholar 

  3. Baxendale, S. & Heaney, D. Memory complaints in the epilepsy clinic. Pract. Neurol. 21, 25–29 (2020).

    Google Scholar 

  4. Romoli, M., Sen, A., Parnetti, L., Calabresi, P. & Costa, C. Amyloid-β: a potential link between epilepsy and cognitive decline. Nat. Rev. Neurol. 17, 469–485 (2021).

    Article  CAS  PubMed  Google Scholar 

  5. Costa, C. et al. Alzheimer’s disease and late-onset epilepsy of unknown origin: two faces of beta amyloid pathology. Neurobiol. Aging 73, 61–67 (2019).

    Article  CAS  PubMed  Google Scholar 

  6. Tai, X. Y. et al. Association of dementia risk with focal epilepsy and modifiable cardiovascular risk factors. JAMA Neurol. 80, 445–454 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Sible, I. J. & Nation, D. A. Visit-to-visit blood pressure variability and CSF Alzheimer disease biomarkers in cognitively unimpaired and mildly impaired older adults. Neurology 98, e2446–e2453 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Johnson, E. L. et al. Association between midlife risk factors and late-onset epilepsy: results from the atherosclerosis risk in communities study. JAMA Neurol. 75, 1375–1382 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Kaestner, E. et al. Atrophy and cognitive profiles in older adults with temporal lobe epilepsy are similar to mild cognitive impairment. Brain 144, 236–250 (2021).

    Article  PubMed  Google Scholar 

  10. Johnson, E. L. et al. Dementia in late-onset epilepsy: the Atherosclerosis Risk in Communities study. Neurology 95, e3248–e3256 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Cinzia Costa.

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Romoli, M., Costa, C. Cardiovascular risk factors for epilepsy and dementia. Nat Rev Neurol 19, 391–392 (2023).

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