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Parkinson disease

A seed amplification assay to detect Parkinson disease pathology

Nature Reviews Neurology volume 19, page 324 (2023)Cite this article

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An α-synuclein seed amplification assay (SAA) can reliably identify people with Parkinson disease (PD), even at the prodromal stage, research recently published in The Lancet Neurology indicates. Aggregated α-synuclein is the main constituent of the intraneuronal Lewy bodies that are found in the brains of people with PD. In the new study, Andrew Siderowf, Luis Concha-Marambio and colleagues used an SAA to detect aggregation-prone α-synuclein in the cerebrospinal fluid (CSF).

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References

Original article

  • Siderowf, A. et al. Assessment of heterogeneity among participants in the Parkinson’s Progression Markers Initiative cohort using α-synuclein seed amplification: a cross-sectional study. Lancet Neurol. 22, 407–417 (2023)

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Related articles

  • Concha-Marambio, L. et al. Seed amplification assay for the detection of pathologic alpha-synuclein aggregates in cerebrospinal fluid. Nat. Protoc. 18, 1179–1196 (2023)

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  • Concha-Marambio, L. et al. Accurate detection of α-synuclein seeds in cerebrospinal fluid from isolated rapid eye movement sleep behavior disorder and patients with Parkinson’s disease in the DeNovo Parkinson (DeNoPa) cohort. Mov. Disord. 38, 567–578 (2023)

    Article  CAS  PubMed  Google Scholar 

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  1. Nature Reviews Neurology http://www.nature.com/nrneurol/

    Heather Wood

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  1. Heather Wood
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Correspondence to Heather Wood.

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Wood, H. A seed amplification assay to detect Parkinson disease pathology. Nat Rev Neurol 19, 324 (2023). https://doi.org/10.1038/s41582-023-00814-1

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  • DOI: https://doi.org/10.1038/s41582-023-00814-1

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