A growing understanding of the neurobiology of psychosis offers hope for an improvement in the standard of care; this includes the development of individualized, precision therapeutics. However, the path to precision psychiatry is long, and progress would be accelerated by greater collaboration with the fields of neurology and neuroscience.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Hyman, S. E. Revolution stalled. Sci. Transl. Med. 4, 155cm11 (2012).
US FDA. Precision medicine. US Food and Drug Administration https://www.fda.gov/medical-devices/in-vitro-diagnostics/precision-medicine (2018).
Espay, A. J. et al. Current concepts in diagnosis and treatment of functional neurological disorders. JAMA Neurol. 75, 1132–1141 (2018).
Clementz, B. A. et al. Psychosis biotypes: replication and validation from the B-SNIP Consortium. Schizophr. Bull. 48, 56–68 (2022).
Rosenthal, L. S. et al. The NINDS Parkinson’s disease biomarkers program. Mov. Disord. 31, 915–923 (2016).
Beauchaine, T. P., Constantino, J. N. & Hayden, E. P. Psychiatry and developmental psychopathology: unifying themes and future directions. Compr. Psychiatry 87, 143–152 (2018).
Gong, C. X., Dai, C. L., Liu, F. & Iqbal, K. Multi-targets: an unconventional drug development strategy for Alzheimer’s disease. Front. Aging Neurosci. 14, 837649 (2022).
El-Alti, L., Sandman, L. & Munthe, C. Person centered care and personalized medicine: irreconcilable opposites or potential companions? Health Care Anal. 27, 45–59 (2019).
Keshavan, M. S., Price, B. H. & Martin, J. B. The convergence of neurology and psychiatry: the importance of cross-disciplinary education. J. Am. Med. Assoc. 324, 554–555 (2020).
Samanta, D. GRIN2A-related epilepsy and speech disorders: a comprehensive overview with a focus on the role of precision therapeutics. Epilepsy Res. 189, 107065 (2023).
The authors thank J. McDowell and V. Shashi for their valuable input.
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Keshavan, M.S., Clementz, B.A. Precision medicine for psychosis: a revolution at the interface of psychiatry and neurology. Nat Rev Neurol 19, 193–194 (2023). https://doi.org/10.1038/s41582-023-00788-0