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Neurodegenerative disease

WNT receptor variant linked to synaptic degeneration

Nature Reviews Neurology volume 19, page 129 (2023)Cite this article

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A genetic variant of the WNT receptor LRP6 exacerbates synapse degeneration in mouse models of ageing and Alzheimer’s disease (AD), according to new research reported in Science Advances. The LRP6-Val variant, which results in replacement of isoleucine with valine at amino acid 1062 of LRP6, is associated with late-onset AD, and the findings provide clues to the mechanisms that could underlie this relationship.

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References

Original article

  • Jones, M. E. et al. A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer’s disease. Sci. Adv. 9, eabo7421 (2023)

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Related articles

  • Tzioras, M. et al. Synaptic degeneration in Alzheimer disease. Nat. Rev. Neurol. 19, 19–38 (2023);

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  • De Ferrari, G. V. et al. Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer’s disease. Proc. Natl Acad. Sci. USA 104, 9434–9439 (2007)

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  1. Nature Reviews Neurology http://www.nature.com/nrneurol/

    Heather Wood

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  1. Heather Wood
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Correspondence to Heather Wood.

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Wood, H. WNT receptor variant linked to synaptic degeneration. Nat Rev Neurol 19, 129 (2023). https://doi.org/10.1038/s41582-023-00781-7

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  • DOI: https://doi.org/10.1038/s41582-023-00781-7

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