The results of the first randomized, placebo-controlled trial of dimethyl fumarate in a cohort of participants with radiologically isolated syndrome showed efficacy against the risk of a first clinical demyelinating event. The findings pave the way for preventive medicine in multiple sclerosis and highlight the need for more precise prognostication of risk.
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M.P.A. served on scientific advisory boards for and has received speaker honoraria and research support from Bayer Schering Pharma, Biogen Idec, Cellgene BMS, Merck Serono, Novartis, Roche and Sanofi Aventis; is co-Editor of Multiple Sclerosis journal; and serves on the editorial board of BMC Neurology. E.P. received compensation for travel grants, participation in advisory board and/or speaking activities from Biogen, Cellgene BMS, Merck Serono, Novartis, Roche, Sanofi and Teva; and serves on the editorial board of Frontiers in Neurology and Brain Sciences.
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Amato, M.P., Portaccio, E. A first step towards preventive medicine in multiple sclerosis. Nat Rev Neurol 19, 134–135 (2023). https://doi.org/10.1038/s41582-022-00769-9