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‘On-demand’ gene therapy for epilepsy


Gene therapies show promise for treating epilepsy, but most strategies target cells across an entire brain region rather than selecting pathologically hyperexcited neurons. Researchers have now developed a conditional gene therapy strategy that downregulates firing activity only in neurons that are pathologically overactive and switches off when brain circuit activity has returned to baseline.

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Correspondence to Pasquale Striano.

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The authors declare no competing interests.

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Striano, P., Benfenati, F. ‘On-demand’ gene therapy for epilepsy. Nat Rev Neurol 19, 130–131 (2023).

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