In a study of 17,000 Medicare beneficiaries with mild cognitive impairment or dementia, non-Hispanic white older adults were more likely than Asian, Black or Hispanic older adults to have elevated cortical amyloid, as measured by PET. These findings have important implications for the use of amyloid-targeting therapies.
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Chen, C. & Zissimopoulos, J. M. Racial and ethnic differences in trends in dementia prevalence and risk factors in the United States. Alzheimers Dement. (NY) 4, 510–520 (2018).
Wilkins, C. H. et al. Racial and ethnic differences in amyloid PET positivity in individuals with mild cognitive impairment or dementia: a secondary analysis of the Imaging Dementia-Evidence for Amyloid Scanning (IDEAS) cohort study. JAMA Neurol. https://doi.org/10.1001/JAMANEUROL.2022.3157 (2022).
Rabinovici, G. D. et al. Association of amyloid positron emission tomography with subsequent change in clinical management among medicare beneficiaries with mild cognitive impairment or dementia. J. Am. Med. Assoc. 321, 1286–1294 (2019).
Gottesman, R. F. et al. The ARIC-PET amyloid imaging study: brain amyloid differences by age, race, sex, and APOE. Neurology 87, 473–480 (2016).
Meeker, K. L. et al. Socioeconomic status mediates racial differences seen using the AT(N) framework. Ann. Neurol. 89, 254–265 (2021).
Deters, K. D. et al. Amyloid PET imaging in self-identified non-hispanic black participants of the Anti-Amyloid in Asymptomatic Alzheimer’s disease (A4) study. Neurology 96, e1491–e1500 (2021).
Barnes, L. L. et al. Mixed pathology is more likely in black than white decedents with Alzheimer dementia. Neurology 85, 528–534 (2015).
Gleason, C. E. et al. Association between enrollment factors and incident cognitive impairment in Blacks and whites: data from the Alzheimer’s Disease Center. Alzheimers Dement. 15, 1533–1545 (2019).
Powell, W. R. et al. Association of neighborhood-level disadvantage with Alzheimer disease neuropathology. JAMA Netw. Open 3, e207559 (2020).
Gottesman, R. F. et al. Association between midlife vascular risk factors and estimated brain amyloid deposition. J. Am. Med. Assoc. 317, 1443–1450 (2017).
The authors are supported by the Intramural Research Program of the NIH, National Institute on Aging.
The authors declare no competing interests.
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Dark, H.E., Walker, K.A. New IDEAS about amyloid, race and dementia disparities. Nat Rev Neurol (2022). https://doi.org/10.1038/s41582-022-00748-0