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ALZHEIMER DISEASE

Neuropsychiatric symptoms in AD: the search for mechanisms

New work building on the results of genome-wide association studies in Alzheimer disease has identified molecular mechanisms that are shared with some psychiatric disorders. The study leveraged ‘omics data and has the realistic potential to elucidate unknown disease mechanisms; however, a lack of information about neuropsychiatric symptoms in the participants with Alzheimer disease limits the conclusions.

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References

  1. Steinberg, M. et al. Point and 5-year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study. Int. J. Geriatr. Psychiatry 23, 170–177 (2008).

    Article  Google Scholar 

  2. Maust, D. T. et al. Antipsychotics, other psychotropics, and the risk of death in patients with dementia: number needed to harm. JAMA Psychiatry 72, 438–445 (2015).

    Article  Google Scholar 

  3. Wingo, T. S. et al. Shared mechanisms across the major psychiatric and neurodegenerative diseases. Nat. Commun. 13, 4314 (2022).

    Article  CAS  Google Scholar 

  4. Ismail, Z. et al. Psychosis in Alzheimer disease — mechanisms, genetics and therapeutic opportunities. Nat. Rev. Neurol. 18, 131–144 (2022).

    Article  Google Scholar 

  5. DeMichele-Sweet, M. A. A. et al. Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease. Mol. Psychiatry 26, 5797–5811 (2021).

    Article  CAS  Google Scholar 

  6. Pishva, E. et al. Psychosis-associated DNA methylomic variation in Alzheimer’s disease cortex. Neurobiol. Aging 89, 83–88 (2020).

    Article  CAS  Google Scholar 

  7. Creese, B. et al. Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer’s disease. Transl. Psychiatry 9, 273 (2019).

    Article  Google Scholar 

  8. Johar, I. et al. Genome-wide association of Alzheimer’s disease with dysphoria and evaluation of genetic overlap with major depressive disorder. Alzheimers Dement. 15, 621–622 (2019).

    Article  Google Scholar 

Download references

Acknowledgements

B.C. and K.L. are supported by the National Institute On Aging of the National Institutes of Health under award number R01AG067015. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Correspondence to Byron Creese.

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Creese, B., Lunnon, K. Neuropsychiatric symptoms in AD: the search for mechanisms. Nat Rev Neurol 18, 639–640 (2022). https://doi.org/10.1038/s41582-022-00721-x

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