A new longitudinal study involving carriers of amyotrophic lateral sclerosis (ALS)-associated mutations has identified a prodromal phase of ALS characterized by mild motor impairment. The findings could help us to define a time window during which neuroprotective interventions might be effective in patients with genetic forms of ALS.
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The author declares no competing interests.
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de Carvalho, M. Monitoring disease onset in amyotrophic lateral sclerosis. Nat Rev Neurol 18, 513–514 (2022). https://doi.org/10.1038/s41582-022-00696-9