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MOTOR NEURON DISEASE

Monitoring disease onset in amyotrophic lateral sclerosis

Nature Reviews Neurology volume 18, pages 513–514 (2022)Cite this article

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A new longitudinal study involving carriers of amyotrophic lateral sclerosis (ALS)-associated mutations has identified a prodromal phase of ALS characterized by mild motor impairment. The findings could help us to define a time window during which neuroprotective interventions might be effective in patients with genetic forms of ALS.

Refers to Benatar, M. et al. Mild motor impairment as prodromal state in amyotrophic lateral sclerosis: a new diagnostic entity. Brain https://doi.org/10.1093/brain/awac185 (2022).

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Authors and Affiliations

  1. Instituto de Fisiologia, Instituto de Medicina Molecular, Centro de Estudos Egas Moniz, Faculdade de Medicina, Univeridade de Lisboa, Lisbon, Portugal

    Mamede de Carvalho

  2. Department of Neurosciences and Mental Health, Hospital de Santa Maria, Centro Hospitalar Universitário de Lisboa Norte, Lisbon, Portugal

    Mamede de Carvalho

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  1. Mamede de Carvalho
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Correspondence to Mamede de Carvalho.

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de Carvalho, M. Monitoring disease onset in amyotrophic lateral sclerosis. Nat Rev Neurol 18, 513–514 (2022). https://doi.org/10.1038/s41582-022-00696-9

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  • DOI: https://doi.org/10.1038/s41582-022-00696-9

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