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ALZHEIMER DISEASE

Genome-wide analysis furthers decoding of Alzheimer disease genetics

Nature Reviews Neurology (2022)Cite this article

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A new genome-wide association study has identified 41 previously unknown loci associated with Alzheimer disease. However, these data provide limited insight into disease mechanisms or benefits for clinical prediction of Alzheimer disease.

Refers to Bellenguez, C. et al. New insights into the genetic aetiology of Alzheimer’s disease and related dementias. Nat. Genet. https://doi.org/10.1038/s41588-022-01024-z (2022).

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Fig. 1: Overlap between risk loci in Alzheimer disease identified in the two largest and most recent genome-wide association studies (GWAS) in the field.

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Acknowledgements

Both authors are supported by grants from the Deutsche Forschungsgemeinschaft (DFG), the European Research Council (ERC) and the Cure Alzheimer’s Fund (CAF). C.M.L. is also supported by the Michael J. Fox Foundation for Parkinson’s Research.

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Authors and Affiliations

  1. Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Lübeck, Germany

    Christina M. Lill & Lars Bertram

  2. Ageing Epidemiology Unit (AGE), School of Public Health, Imperial College London, London, UK

    Christina M. Lill

  3. Centre for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway

    Lars Bertram

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  1. Christina M. Lill
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  2. Lars Bertram
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Correspondence to Lars Bertram.

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Lill, C.M., Bertram, L. Genome-wide analysis furthers decoding of Alzheimer disease genetics. Nat Rev Neurol (2022). https://doi.org/10.1038/s41582-022-00678-x

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  • DOI: https://doi.org/10.1038/s41582-022-00678-x

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