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Genome-wide analysis furthers decoding of Alzheimer disease genetics

A new genome-wide association study has identified 41 previously unknown loci associated with Alzheimer disease. However, these data provide limited insight into disease mechanisms or benefits for clinical prediction of Alzheimer disease.

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Fig. 1: Overlap between risk loci in Alzheimer disease identified in the two largest and most recent genome-wide association studies (GWAS) in the field.


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Both authors are supported by grants from the Deutsche Forschungsgemeinschaft (DFG), the European Research Council (ERC) and the Cure Alzheimer’s Fund (CAF). C.M.L. is also supported by the Michael J. Fox Foundation for Parkinson’s Research.

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Correspondence to Lars Bertram.

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Lill, C.M., Bertram, L. Genome-wide analysis furthers decoding of Alzheimer disease genetics. Nat Rev Neurol (2022).

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