A new paper published in Neuron presents an analysis of mRNA expression in human and mouse trigeminal ganglia at single-nucleus resolution. The resulting resource is thought-provoking and suggests new targets for pain therapies; however, the findings should be interpreted in the context of the available protein data and warrant functional verification.
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References
Stovner, L. J. et al. The global burden of headache: a documentation of headache prevalence and disability worldwide. Cephalalgia 27, 193–210 (2007).
Edvinsson, L. & Haanes, K. A. Identifying new antimigraine targets: lessons from molecular biology. Trends Pharmacol. Sci. 42, 217–225 (2021).
Yang, L. et al. Human and mouse trigeminal ganglia cell atlas implicates multiple cell types in migraine. Neuron https://doi.org/10.1016/j.neuron.2022.03.003 (2022).
Grindberg, R. V. et al. RNA-sequencing from single nuclei. Proc. Natl Acad. Sci. USA 110, 19802–19807 (2013).
Edvinsson, J. C. et al. Neurokinins and their receptors in the rat trigeminal system: differential localization and release with implications for migraine pain. Mol. Pain 17, 17448069211059400 (2021).
Edvinsson, J. C. A., Haanes, K. A. & Edvinsson, L. Neuropeptides and the nodes of ranvier in cranial headaches. Front. Physiol. 12, 820037 (2022).
Edvinsson, L., Grell, A. S. & Warfvinge, K. Expression of the CGRP family of neuropeptides and their receptors in the trigeminal ganglion. J. Mol. Neurosci. 70, 930–944 (2020).
Edvinsson, J. C. A. et al. Differences in pituitary adenylate cyclase-activating peptide and calcitonin gene-related peptide release in the trigeminovascular system. Cephalalgia 40, 1296–1309 (2020).
Schytz, H. W. et al. PACAP38 induces migraine-like attacks in patients with migraine without aura. Brain 132, 16–25 (2009).
Ashina, M. et al. A phase 2, randomized, double-blind, placebo-controlled trial of AMG 301, a pituitary adenylate cyclase-activating polypeptide PAC1 receptor monoclonal antibody for migraine prevention. Cephalalgia 41, 33–44 (2021).
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Edvinsson, L., Edvinsson, J.C.A. & Haanes, K.A. Identifying molecular targets in trigeminal nociception. Nat Rev Neurol 18, 385–386 (2022). https://doi.org/10.1038/s41582-022-00671-4
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DOI: https://doi.org/10.1038/s41582-022-00671-4