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Does antiherpetic antiviral therapy reduce the risk of dementia?

Several studies indicate that, in individuals infected with herpes simplex virus and/or varicella zoster virus, antiviral therapy reduces the subsequent risk of Alzheimer disease and other types of dementia. As highlighted in this article, the preventative potential of antiviral therapy would probably be maximized by treating asymptomatic as well as symptomatic infected individuals.

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The author thanks the Advantage Foundation for financial support.

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Correspondence to Ruth F. Itzhaki.

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Itzhaki, R.F. Does antiherpetic antiviral therapy reduce the risk of dementia?. Nat Rev Neurol 18, 63–64 (2022).

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