Correction to: Nature Reviews Neurology https://doi.org/10.1038/s41582-021-00549-x, published online 14 September 2021.

In the originally published article, the first sentence of the Abstract erroneously included the word ‘that’ before the word ‘pathological’. The correct version reads as follows: “Dysregulation of the immune system is a cardinal feature of Alzheimer disease (AD), and a considerable body of evidence indicates pathological alterations in central and peripheral immune responses that change over time.” In addition, during manuscript preparation, a key reference (Da Mesquita, S., Fu, Z. & Kipnis, J. The meningeal lymphatic system: a new player in neurophysiology. Neuron 100, 375–388 (2018)) was inadvertently omitted from the section entitled The role of adaptive immunity and the lymphatic–glymphatic system. The reference has now been added. These corrections have both been made in the HTML and PDF versions of the paper.