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EPILEPSY

Cortical thinning in epilepsy is linked to microglial activation

Nature Reviews Neurology volume 17, page 595 (2021)Cite this article

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Cortical thinning in the brains of people with epilepsy correlates with the distribution of activated microglia, new research published in Neuropathology and Applied Neurobiology indicates. The study, conducted by the ENIGMA-Epilepsy Working Group, also showed that transient microglial depletion prevented seizure-associated cortical thinning in mice, suggesting a potential strategy to protect the cortex from seizure-induced damage.

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  • Whelan, C. D. et al. Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study. Brain 141, 391–408 (2018)

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  1. Nature Reviews Neurology http://www.nature.com/nrneurol/

    Heather Wood

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  1. Heather Wood
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Correspondence to Heather Wood.

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Wood, H. Cortical thinning in epilepsy is linked to microglial activation. Nat Rev Neurol 17, 595 (2021). https://doi.org/10.1038/s41582-021-00559-9

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  • DOI: https://doi.org/10.1038/s41582-021-00559-9

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