Correction to: Nature Reviews Neurology https://doi.org/10.1038/s41582-021-00529-1, published online 20 July 2021.

In the originally published version of this article, the terms ‘early-onset MCI’ and ‘late-onset MCI’ were erroneously used in the sixth paragraph of the section entitled ‘Aβ-associated changes’. The correct terms are ‘early-stage MCI’ and ‘late-stage MCI’. Moreover, studies by Lee et al. (ref. 174) and Buckner et al. (ref. 175) were incorrectly discussed and cited in the first paragraph of the section entitled ‘Early-onset AD’. These studies should instead be cited after ‘prodromal AD’ in the below sentence in the fifth paragraph of the section entitled ‘Aβ-associated changes’:

Several subsequent studies have found evidence that the association between Aβ pathology and decreased DMN (in particular, the posteromedial components of DMN) connectivity is also identifiable in preclinical AD3,104,105, prodromal AD106,107 and early-onset AD108.

Last, in the description of the neuropathological hallmarks of Alzheimer disease in the first paragraph of the introduction, the terms ‘extracellular’ and ‘intracellular’ were transposed. The description should read: ‘Biologically, AD is defined by two principal neuropathological hallmarks: the abnormal accumulation of extracellular amyloid-β (Aβ)-containing plaques and intracellular tau-containing neurofibrillary tangles.’

These errors have been corrected in the HTML and PDF versions of the article.