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The Parkinson disease connectome — insights from new imaging studies

During Parkinson disease progression, the accumulation of α-synuclein pathology is paralleled by changes in structural and functional connectivity in the brain. Two new studies pinpoint specific alterations in the brain connectome in the early stages of Parkinson disease and suggest future avenues of research to develop connectome-based biomarkers.

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Correspondence to Klaus Seppi.

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Krismer, F., Seppi, K. The Parkinson disease connectome — insights from new imaging studies. Nat Rev Neurol 17, 527–528 (2021).

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