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Microglial optogenetics triggers chronic pain in mice

Nature Reviews Neurology volume 17, page 262 (2021)Cite this article

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Activation of microglia is sufficient to trigger chronic pain in mice, according to a new study published recently in PLoS Biology. Innovative use of optogenetics enabled selective manipulation of microglia, demonstrating a technique that could be used to study microglial involvement in other diseases.

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Original article

  • Yi, M.-H. et al. Optogenetic activation of spinal microglia triggers chronic pain in mice. PLoS Biol. 19, e3001154 (2021)

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  1. Nature Reviews Neurology http://www.nature.com/nrneurol/

    Ian Fyfe

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  1. Ian Fyfe
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Correspondence to Ian Fyfe.

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Fyfe, I. Microglial optogenetics triggers chronic pain in mice. Nat Rev Neurol 17, 262 (2021). https://doi.org/10.1038/s41582-021-00490-z

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  • DOI: https://doi.org/10.1038/s41582-021-00490-z

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