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HEADACHE

Making headway — a role for CGRP in post-traumatic headache

Nature Reviews Neurology volume 17, pages 133–134 (2021)Cite this article

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Although common, post-traumatic headache remains poorly understood and poorly treated. New data have implicated calcitonin gene-related peptide and the trigeminovascular system in this disorder, opening up new avenues for research into its pathophysiology and treatment.

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References

  1. Ashina, H. et al. Post-traumatic headache: epidemiology and pathophysiological insights. Nat. Rev. Neurol. 15, 607–617 (2019).

    Article  Google Scholar 

  2. Bree, D., Stratton, J. & Levy, D. Increased severity of closed head injury or repetitive subconcussive head impacts enhances post-traumatic headache-like behaviors in a rat model. Cephalalgia 20, 1224–1239 (2020).

    Article  Google Scholar 

  3. Navratilova, E. et al. CGRP-dependent and independent mechanisms of acute and persistent post-traumatic headache following mild traumatic brain injury in mice. Cephalalgia 39, 1762–1775 (2019).

    Article  Google Scholar 

  4. Larsen, E. L. et al. Acute and preventive pharmacological treatment of post-traumatic headache: a systematic review. J. Headache Pain 20, 98–106 (2019).

    Article  Google Scholar 

  5. Ashina, H. et al. Hypersensitivity to calcitonin gene-related peptide in post-traumatic headache. Ann. Neurol. https://doi.org/10.1002/ana.25915 (2020).

    Article  PubMed  Google Scholar 

  6. Hadjikhani, N. et al. Extra-axial inflammatory signal in parameninges in migraine with visual aura. Ann Neurol. 87, 939–949 (2020).

    Article  Google Scholar 

  7. Ashina, M. et al. Migraine and the trigeminovascular system- 40 years and counting. Lancet Neurol. 18, 1864–1877 (2020).

    Google Scholar 

  8. Charles, A. & Pozo-Rosich, P. Targeting calcitonin gene-related peptide: a new era in migraine therapy. Lancet 394, 1765–1774 (2019).

    Article  Google Scholar 

  9. Hansen, J. M., Hauge, A. W., Olesen, J. & Ashina, M. Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura. Cephalalgia 30, 1179–1186 (2010).

    Article  Google Scholar 

  10. Ashina, H. et al. Efficacy, tolerability, and safety of erenumab for the preventive treatment of persistent post-traumatic headache attributed to mild traumatic brain injury: an open-label study. J. Headache Pain 21, 62–70 (2020).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. 1st Neurology Department, Aeginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

    Dimos D. Mitsikostas

  2. Departments of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA

    Michael A. Moskowitz

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  1. Dimos D. Mitsikostas
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  2. Michael A. Moskowitz
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Correspondence to Dimos D. Mitsikostas.

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Competing interests

D.D.M. has received honoraria and research or travel grants from Amgen, Allergan, Biogen, Genesis Pharma, Eli Lily, Novartis, Merz, Roche, Specifar, Teva. M.A.M. declares no competing interests.

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Mitsikostas, D.D., Moskowitz, M.A. Making headway — a role for CGRP in post-traumatic headache. Nat Rev Neurol 17, 133–134 (2021). https://doi.org/10.1038/s41582-020-00431-2

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