Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

MULTIPLE SCLEROSIS

Mounting evidence for a multiple sclerosis prodrome

A new study provides direct biological evidence for a prodromal phase of multiple sclerosis (MS), with implications for studying disease aetiology and underscoring the limitations of therapies that solely target inflammation. The findings also suggest an opportunity to apply secondary prevention strategies at the very earliest stages of the disease.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Bjornevik, K. et al. Serum neurofilament light chain levels in patients with presymptomatic multiple sclerosis. JAMA Neurol. https://doi.org/10.1001/jamaneurol.2019.3238 (2019).

    Article  PubMed  Google Scholar 

  2. 2.

    Mankia, K. & Emery, P. Review: Preclinical rheumatoid arthritis: progress toward prevention. Arthritis Rheumatol. 68, 779–788 (2016).

    Article  Google Scholar 

  3. 3.

    Berg, D. et al. MDS research criteria for prodromal Parkinson’s disease. Mov. Disord. 30, 1600–1611 (2015).

    Article  Google Scholar 

  4. 4.

    Okuda, D. T. et al. Radiologically isolated syndrome: 5-year risk for an initial clinical event. PLoS ONE 9, e90509 (2014).

    Article  Google Scholar 

  5. 5.

    Wijnands, J. M. A. et al. Health-care use before a first demyelinating event suggestive of a multiple sclerosis prodrome: a matched cohort study. Lancet Neurol. 16, 445–451 (2017).

    Article  Google Scholar 

  6. 6.

    Wijnands, J. M. et al. Five years before multiple sclerosis onset: phenotyping the prodrome. Mult. Scler. 25, 1092–1101 (2019).

    Article  Google Scholar 

  7. 7.

    Disanto, G. et al. Prodromal symptoms of multiple sclerosis in primary care. Ann. Neurol. 83, 1162–1173 (2018).

    Article  Google Scholar 

  8. 8.

    Wiberg, M. et al. Earnings among people with multiple sclerosis compared to references, in total and by educational level and type of occupation: a population-based cohort study at different points in time. BMJ Open 9, e024836 (2019).

    Article  Google Scholar 

  9. 9.

    Cortese, M. et al. Pre-clinical disease activity in multiple sclerosis: a prospective study on cognitive performance prior to first symptom. Ann. Neurol. 80, 616–624 (2016).

    Article  Google Scholar 

  10. 10.

    US National Library of Medicine. Clinicaltrials.gov https://clinicaltrials.gov/ct2/show/NCT02603146 (2019).

Download references

Acknowledgements

This article was supported (in part) by a Manitoba Research Chair from Research Manitoba, and the Waugh Family Chair in Multiple Sclerosis.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Ruth Ann Marrie.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Marrie, R.A. Mounting evidence for a multiple sclerosis prodrome. Nat Rev Neurol 15, 689–690 (2019). https://doi.org/10.1038/s41582-019-0283-0

Download citation

Further reading

Search

Quick links