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Mounting evidence for a multiple sclerosis prodrome

A new study provides direct biological evidence for a prodromal phase of multiple sclerosis (MS), with implications for studying disease aetiology and underscoring the limitations of therapies that solely target inflammation. The findings also suggest an opportunity to apply secondary prevention strategies at the very earliest stages of the disease.

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This article was supported (in part) by a Manitoba Research Chair from Research Manitoba, and the Waugh Family Chair in Multiple Sclerosis.

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Correspondence to Ruth Ann Marrie.

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The author declares no competing interests.

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Marrie, R.A. Mounting evidence for a multiple sclerosis prodrome. Nat Rev Neurol 15, 689–690 (2019).

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